3^rd International Summit on Hormonal Disorders November 18-19, 2024 Madrid, Spain

Hypopituitarism is a condition characterized by underactivity of the pituitary gland, resulting in insufficient production of one or more hormones normally secreted by the gland. The pituitary gland, often referred to as the "master gland," plays a crucial role in regulating hormone production and controlling various bodily functions. Causes of hypopituitarism can vary and may include: Pituitary tumors, Pituitary surgery or radiation therapy, Trauma, Infections or inflammation, Genetic factors, Hypopituitarism can affect multiple hormone axes controlled by the pituitary gland, leading to a wide range of symptoms depending on which hormones are deficient.

Pituitary adenomas are benign tumors that develop in the pituitary gland, a small gland located at the base of the brain. Despite being non-cancerous, pituitary adenomas can cause hormonal imbalances and disrupt normal pituitary function due to their size and location. Diagnosis of pituitary adenomas involves a combination of imaging studies, such as MRI or CT scans, to visualize the tumor, along with hormonal tests to assess hormone levels and identify any hormonal imbalances.

Hypoparathyroidism is a rare endocrine disorder characterized by insufficient production or activity of parathyroid hormone (PTH), resulting in low levels of calcium in the blood (hypocalcemia) and high levels of phosphate. Common causes of hypoparathyroidism include surgical removal of the parathyroid glands (such as during thyroid surgery), autoimmune destruction of the parathyroid glands (as in autoimmune polyendocrine syndrome), genetic disorders (such as DiGeorge syndrome), or injury to the parathyroid glands.

Hyperparathyroidism is a condition characterized by over activity of the parathyroid glands, leading to excessive production of parathyroid hormone (PTH). In hyperparathyroidism, elevated levels of PTH cause an increase in calcium levels in the blood (hypercalcemia). This can lead to a variety of symptoms and complications, including, Bone loss, Digestive issues, Cognitive changes, Cardiovascular complications. Diagnosis of hyperparathyroidism involves blood tests to measure calcium and PTH levels, as well as imaging studies such as ultrasound or sestamibi scan to locate any abnormal parathyroid glands.

Acromegaly is a rare hormonal disorder caused by the overproduction of growth hormone (GH) in adulthood. It typically occurs due to a benign tumor (adenoma) of the pituitary gland, although in rare cases, it can result from tumors elsewhere in the body that produce growth hormone-releasing hormone (GHRH). Excess GH leads to abnormal growth of tissues and organs, resulting in characteristic physical changes such as enlargement of the hands, feet, and facial features. Other symptoms may include joint pain, enlarged organs (such as the heart), thickening of the skin, sleep apnea, fatigue, headaches, and vision problems.

Growth hormone deficiency (GHD) is a medical condition characterized by insufficient production of growth hormone (GH) by the pituitary gland. Growth hormone deficiency can occur at any age, but it is most commonly diagnosed in childhood when it can lead to short stature and growth failure. In adults, GHD can cause a range of symptoms, including decreased muscle mass, increased body fat, fatigue, decreased bone density, impaired cognitive function, and reduced quality of life.

Cushing's syndrome is a hormonal disorder characterized by prolonged exposure to high levels of cortisol, a steroid hormone produced by the adrenal glands. There are several possible causes of Cushing's syndrome, including This can occur due to adrenal tumors such as carcinomas that produce excess cortisol independent of normal regulatory mechanisms. Most cases of Cushing's syndrome result from overproduction of adrenocorticotropic hormone (ACTH) by a benign tumor (adenoma) in the pituitary gland. This tumor causes the adrenal glands to produce excess cortisol. In rare cases, tumors outside the pituitary or adrenal glands, such as in the lungs or pancreas, can produce ACTH, leading to increased cortisol production.

Goiter refers to the abnormal enlargement of the thyroid gland, causing swelling or protrusion in the neck. It can occur due to various reasons, including iodine deficiency, autoimmune thyroiditis (such as Hashimoto's thyroiditis), or the presence of thyroid nodules. Symptoms of goiter may include a visible swelling in the neck, difficulty swallowing or breathing, coughing, or hoarseness. Diagnosis of goiter involves physical examination, imaging tests (such as ultrasound), and blood tests to evaluate thyroid function and rule out underlying causes.

Thyroid nodules are lumps or growths that develop within the thyroid gland. Most thyroid nodules are benign (non-cancerous) and do not cause symptoms. While the majority of thyroid nodules are harmless, some may cause symptoms such as difficulty swallowing, hoarseness, or visible neck swelling. Diagnosis of thyroid nodules typically involves imaging tests such as ultrasound, along with fine-needle aspiration biopsy to determine whether the nodule is benign or cancerous.

Thyrotoxicosis is a common endocrine disorder characterized by an overactive thyroid gland, leading to excessive production of thyroid hormones. The most common cause of hyperthyroidism is an autoimmune condition known as Graves' disease, where the body's immune system mistakenly attacks the thyroid gland, causing it to produce too much thyroid hormone. Symptoms of hyperthyroidism may include weight loss, increased appetite, rapid heartbeat (tachycardia), palpitations, sweating, heat intolerance, tremors, anxiety, irritability, fatigue, muscle weakness, and changes in menstrual patterns.

Hypothyroidism is a common Hormonal disorder characterized by an underactive thyroid gland, which fails to produce enough thyroid hormone to meet the body's needs. Causes of hypothyroidism include autoimmune thyroiditis (Hashimoto's thyroiditis), thyroid surgery or radiation therapy, certain medications, congenital thyroid defects, and iodine deficiency. Symptoms of hypothyroidism can vary widely but may include fatigue, weight gain, sensitivity to cold, dry skin, hair loss, constipation, depression, muscle weakness, joint pain, and menstrual irregularities in women.

This type of diabetes occurs during pregnancy and usually resolves after childbirth. It is characterized by high blood sugar levels that develop during pregnancy in women who did not have diabetes before pregnancy. Gestational diabetes increases the risk of complications during pregnancy and delivery and may also increase the risk of type 2 diabetes later in life for both the mother and child.

In type 2 diabetes, the body becomes resistant to the effects of insulin or the pancreas does not produce enough insulin to meet the body's needs. This leads to elevated blood sugar levels. Type 2 diabetes is more common than type 1 and is often associated with lifestyle factors such as obesity, physical inactivity, and poor diet. It typically develops in adults, but increasingly affects children and adolescents due to rising obesity rates. Type 2 diabetes can often be managed with lifestyle modifications, oral medications, and/or insulin therapy.

This autoimmune condition occurs when the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the pancreas produces little to no insulin. Type 1 diabetes typically develops in childhood or adolescence, although it can occur at any age. People with type 1 diabetes require lifelong insulin therapy to manage their blood sugar levels.

Addison's disease, also known as primary adrenal insufficiency, is a rare but serious endocrine disorder characterized by insufficient production of hormones by the adrenal glands. The most common cause of Addison's disease is autoimmune destruction of the adrenal cortex. Symptoms of  disease can be nonspecific and may include decreased appetite, abdominal pain, nausea, vomiting, diarrhea, hypotension, dizziness, salt craving, hyperpigmentation , and changes in mood or behavior.

Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting people with ovaries, typically during their reproductive years. PCOS is characterized by a combination of symptoms related to hormonal imbalances and metabolic issues.The cause of PCOS is involves a combination of genetic, hormonal, and environmental factors.Symptoms of PCOS can vary widely among individuals and may include irregular periods, infertility, weight gain, acne, hirsutism, hair loss, and mood disturbances

Diagnosis of PCOS typically involves a combination of medical history, physical examination, blood tests to assess hormone levels (including androgens and insulin), and imaging studies such as pelvic ultrasound to evaluate the ovaries.